Improved pulse wave velocity wave front detection by template-matching

Background Pressure waves distributed through the aorta by left ventricular contraction propagate at a rate known as the pulse wave velocity (PWV). PWV is a measure of aortic stiffness, and increased PWV has been correlated with increased coronary artery disease risk. PWV can be measured by velocity-encoded magnetic resonance (PCMR), with velocity profiles collected at a minimum of two locations along the vessel. The commonly used simple linear regression method computes PWV from detected wavefronts in each profile and distance along the aorta. Recognizing the limitation imposed on wave front detection by simple maximum impulse by noise in the signal producing local maxima, we designed and tested a template-matching scheme to improve PWV estimation.